IRBIT activates NBCe1‐B by releasing the auto‐inhibition module from the transmembrane domain
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چکیده
منابع مشابه
PlexinA1 Autoinhibition by the Plexin Sema Domain
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Nedd4 E3 ligases are members of the HECT E3 ubiquitin ligase family and regulate ubiquitination-mediated protein degradation. In this report, we demonstrate that calcium releases the C2 domain-mediated auto-inhibition in both Nedd4-1 and Nedd4-2. Calcium disrupts binding of the C2 domain to the HECT domain. Consistent with this, calcium activates the E3 ubiquitin ligase activity of Nedd4. Eleva...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2020
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jp280578